Gelatinaz A - Gelatinase A

Gelatinaz A
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Gelatinaz A, inson
Identifikatorlar
EC raqami3.4.24.24
CAS raqami146480-35-5
Ma'lumotlar bazalari
IntEnzIntEnz ko'rinishi
BRENDABRENDA kirish
ExPASyNiceZyme ko'rinishi
KEGGKEGG-ga kirish
MetaCycmetabolik yo'l
PRIAMprofil
PDB tuzilmalarRCSB PDB PDBe PDBsum

Jelatinaz A, shuningdek, ma'lum MMP2 (EC 3.4.24.24, 72-kDa jelatinaza, matritsali metalloproteinaza 2, kollagenaza IV turi, 3/4 kollagenaza, matritsali metalloproteinaza 5, A tipidagi 72 kDa jelatinaza, kollagenaza IV, kollagenaza IV turi, MMP 2, IV turdagi kollagen metalloproteinaza, IV turdagi kollagenaza / jelatinaza) an ferment.[1][2][3] Ushbu ferment katalizlar quyidagi kimyoviy reaktsiya

Ajratish jelatin turi I va kollagen IV, V, VII, X. turlari kollagenga o'xshash ketma-ketlikni tozalaydi Pro-Gln-Gly-Ile-Ala-Gly-Gln

Bu sir endopeptidaza ga tegishli peptidaza oila M10.

Adabiyotlar

  1. ^ Murphy G, McAlpine CG, Poll CT, Reynolds JJ (sentyabr 1985). "Jelatin va IV va V kollagen turlarini parchalaydigan suyak metalloproteinazasini tozalash va tavsifi". Biochimica et Biofhysica Acta (BBA) - oqsil tuzilishi va molekulyar enzimologiya. 831 (1): 49–58. doi:10.1016/0167-4838(85)90148-7. PMID  2994741.
  2. ^ Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Grant GA, Seltzer JL, Kronberger A, He CS, Bauer EA, Goldberg GI (may 1988). "H-ras onkogen-transformatsiyalangan odamning bronxial epiteliya hujayralari (TBE-1) bazal membrana kollagenini parchalash qobiliyatiga ega bo'lgan bitta metalloproteaza ajratadi". Biologik kimyo jurnali. 263 (14): 6579–87. PMID  2834383.
  3. ^ Okada Y, Morodomi T, Enghild JJ, Suzuki K, Yasui A, Nakanishi I, Salvesen G, Nagase H (dekabr 1990). "Odamning revmatoid sinovial fibroblastlaridan matritsali metalloproteinaza 2. Prekursorni tozalash va faollashtirish va fermentativ xususiyatlar". Evropa biokimyo jurnali. 194 (3): 721–30. doi:10.1111 / j.1432-1033.1990.tb19462.x. PMID  2269296.

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