C16orf78 - C16orf78 - Wikipedia

Xarakterlanmagan protein C16orf78(NP_653203.1 ) a oqsil odamlarda kodlanganligi xromosoma 16 ochiq o'qish doirasi 78 gen.[1]

Gen

C16orf78 geni (123970 ) plyus ipida 16q12.1 da joylashgan bo'lib, 25609 ga teng bp 49,407,734-49,433,342 dan.[2]

mRNA

Bittasi bor mRNA stenogramma (NM_144602.3 ) va boshqa ma'lum bo'lgan qo'shilish izoformalari yo'q. Umumiy uzunligi 1068 taglik juftlikdan iborat 5 ta ekszon mavjud.[2]

Oqsil

Tartib

C16orf78 - 265 aminokislotalar prognoz qilingan molekulyar og'irligi 30,8 kDal va pI 9,8 dan.[3] U ikkalasiga ham boy metionin va lizin, 6,4% metionin va 13,6% lizindan iborat.[4] Ushbu metionin boyligi a sifatida xizmat qilishi taxmin qilingan mitoxondrial antioksidant.[5]

Transmilliy o'zgarishlar

To'rtta tasdiqlangan hamma joyda saytlar va uchta tasdiqlangan fosforillanish saytlar.[6][7]

Hamma joyda joylashgan joylar qizil va fosforillanish joylari kul rang bilan belgilangan C16orf78 oqsilining diagrammasi.[8]

Tuzilishi

C16orf78 ikkilamchi tuzilishini bashorat qilish asosan quyidagilardan iborat alfa spirallari va o'ralgan sariq.[9][10][11] Phyre2 shuningdek, taxmin qilingan C16orf78 asosan spiraldir, ammo 265 aminokislotadan 253 tasi modellashtirilgan ab initio shuning uchun modelga bo'lgan ishonch past.[12]

Phyre2 tomonidan ishlab chiqarilgan C16orf78 modeli ishlab chiqarilgan Ximera.

Subcellular localization

C16orf78 hujayra yadrosida lokalizatsiya qilinishi taxmin qilinmoqda.[13] Shuningdek, bashorat qilingan ikki tomonlama yadroviy lokalizatsiya signali mavjud.[14]

Ifoda

C16orf78 moyak tomon ekspressionni cheklab qo'ygan, boshqa to'qimalarda esa bu ko'rsatkich ancha past.[15]

C16orf78 ning bir nechta inson to'qimalarida ifodalanishi[16]

O'zaro ta'sir

C16orf78 bilan jismoniy bog'liqlik mavjud DNK / RNK bilan bog'lovchi oqsil KIN17 (NP_036443.1 ), C16orf78 DNKni tiklashda ham rol o'ynashi mumkin.[17] C16orf78 tomonidan fosforillanganligi aniqlandi SRPK1 (NP_003128.3 ) va SPRK2 (AAH68547.1 ).[6]

Klinik ahamiyati

C16orf78 genini yo'q qilish prostata saratoni determinanti sifatida aniqlandi.[18] A SNP C16orf78 da SNP bilan o'zaro ta'sir qiladi LMTK2 va prostata saratoni xavfi bilan bog'liq.[19]

Kuchaytirish C16orf78 genining metabolik moslashuvchan saraton hujayralari bilan aloqasi bor.[20] C16orf78 genining takrorlanishi kamida bitta Rolandic epilepsiya kasalligi bilan bog'liq edi.[21]

Gomologiya

Paraloglar

C16orf78 noma'lum paraloglar odamlarda.[22]

Ortologlar

C16orf78-da 80 dan ortiq ortologlar, shu jumladan, uzoqdagi hayvonlar Ciona intestinalis (XP_002132057.1 ), bu 676 million yil oldin odamlardan ajralib chiqqan deb taxmin qilinadi.[2][23] C16orf78 ko'plab sutemizuvchilar, sudralib yuruvchilar, suyakli baliq, va hatto ba'zi umurtqasizlar, ammo amfibiyalarda yoki qushlarda ma'lum bo'lgan ortologlari yo'q.[22] Quyida divergentsiya sanalari bilan ortologlar namunalari keltirilgan jadval mavjud TimeTree va o'xshashlik juftlikda ketma-ketlikni tekislash.[24]

C16orf78 ortologlari jadvali
Turlarning nomiNCBI-ga kirishDivergensiya (mya) (taxmin qilingan)Uzunlik (aa)Shaxsiyat% O'xshashlik
Homo sapiensNP_653203.10265100%100%
Gorilla gorilla gorillaXP_004057673.29.0626596%98%
Makaka mulattaXP_001082258.129.4426789%93%
Galeopterus variegatusXP_008591134.17626665%77%
Oryctolagus cuniculusXP_008273281.19025562%76%
Muskul mushakNP_808569.19027057%69%
Veksillifer lipotlariXP_007459548.19626665%77%
Capra hircusXP_017918754.19627663%74%
Callorhinus ursinusXP_025708226.19625062%74%
Pteropus vampyrusXP_011358492.19626360%74%
Loxodonta africanaXP_023411324.110528548%55%
Sarcophilus harrisiiXP_003757266.115927038%53%
Vombatus ursinusXP_027723426.115927538%54%
Pogona vititsepslariXP_020643996.131231526%43%
Gekko japonicusXP_015263322.131226125%47%
Python bivittatusXP_025030465.131231323%37%
Latimeriya chalumnaeXP_014344069.141331019%42%
Acipenser ruthenusRXM34621.143520215%37%
Ciona intestinalisXP_002132057.167639610%32%
Apostichopus japonicusPIK46940.16842929%33%

Adabiyotlar

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