At arterivirus serin peptidaza - Equine arterivirus serine peptidase - Wikipedia

At arterivirus serin peptidaza
Identifikatorlar
EC raqami3.4.21.114
Ma'lumotlar bazalari
IntEnzIntEnz ko'rinishi
BRENDABRENDA kirish
ExPASyNiceZyme ko'rinishi
KEGGKEGG-ga kirish
MetaCycmetabolik yo'l
PRIAMprofil
PDB tuzilmalarRCSB PDB PDBe PDBsum

At arterivirus serin peptidaza (EC 3.4.21.114 ) an ferment.[1][2][3] Ushbu ferment katalizlar quyidagi kimyoviy reaktsiya

(Glu / Gln) - (Gly / Ser / Ala) ning ajralishi arterivirus nusxa ko'chirish ORF1a va ORF1ab tarjima mahsulotlarini

In ot arterivirus (EAV), replikatsiya geni tarjima qilinadi ochiq o'qish doirasi 1a (ORF1a) va ORF1ab [poliprotein] lar.

Adabiyotlar

  1. ^ Snijder EJ, Wassenaar AL, van Dinten LC, Spaan WJ, Gorbalenya AE (mart 1996). "Arterivirus nsp4 proteaz - bu ximotripsinga o'xshash fermentlarning yangi guruhi, 3C ga o'xshash serin proteazlarning prototipidir". Biologik kimyo jurnali. 271 (9): 4864–71. doi:10.1074 / jbc.271.9.4864. PMID  8617757.
  2. ^ van Dinten LC, Rensen S, Gorbalenya AE, Snijder EJ (mart 1999). "Arterivirus replikazasining 1b kodlangan qismini o'qish doirasini proteolitik qayta ishlash nsp4 serin proteaz vositachiligida va virusni ko'paytirish uchun juda muhimdir". Virusologiya jurnali. 73 (3): 2027–37. PMC  104445. PMID  9971783.
  3. ^ Barrette-Ng IH, Ng KK, Mark BL, Van Aken D, Cherni MM, Garen C, Kolodenko Y, Gorbalenya AE, Snijder EJ, Jeyms MN (oktyabr 2002). "Arterivirus nsp4 ning tuzilishi. Alfa / beta C-terminal kengaytmasi va oksianion teshigining o'zgaruvchan konformatsiyalari bilan eng kichik ximotripsinga o'xshash proteinaz". Biologik kimyo jurnali. 277 (42): 39960–6. doi:10.1074 / jbc.m206978200. PMID  12163505.

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