Guanozin difosfat mannozi - Guanosine diphosphate mannose - Wikipedia

Guanozin difosfat mannozi
Ismlar
	IUPAC nomi [(2R, 3S, 4R, 5R) -5- (2-amino-6-okso-1,6-dihidro-9H-purin-9-yl) -3,4-dihidroksitetrahidrofuran-2-il] metil (2R , 3S, 4S, 5S, 6R) -3,4,5-trihidroksi-6- (gidroksimetil) tetrahidro-2H-piran-2-il dihidrogen difosfat
Identifikatorlar
CAS raqami	3123-67-9 ;
3D model (JSmol )	Interaktiv rasm;
ChEBI	CHEBI: 15820 ;
ChemSpider	17372 ;
MeSH	Guanosin + Difosfat + Mannoz
PubChem CID	18396;
UNII	SA0B77H8CS ;
	InChI InChI = 1S / C16H25N5O16P2 / c17-16-19-12-6 (13 (28) 20-16) 18-3-21 (12) 14-10 (26) 8 (24) 5 (34-14) 2- 33-38 (29,30) 37-39 (31,32) 36-15-11 (27) 9 (25) 7 (23) 4 (1-22) 35-15 / h3-5,7-11, 14-15,22-27H, 1-2H2, (H, 29,30) (H, 31,32) (H3,17,19,20,28) / t4-, 5-, 7-, 8-, 9 +, 10-, 11 +, 14-, 15- / m1 / s1 Kalit: MVMSCBBUIHUTGJ-GDJBGNAASA-N ; InChI = 1 / C16H25N5O16P2 / c17-16-19-12-6 (13 (28) 20-16) 18-3-21 (12) 14-10 (26) 8 (24) 5 (34-14) 2- 33-38 (29,30) 37-39 (31,32) 36-15-11 (27) 9 (25) 7 (23) 4 (1-22) 35-15 / h3-5,7-11, 14-15,22-27H, 1-2H2, (H, 29,30) (H, 31,32) (H3,17,19,20,28) / t4-, 5-, 7-, 8-, 9 +, 10-, 11 +, 14-, 15- / m1 / s1 Kalit: MVMSCBBUIHUTGJ-GDJBGNAABK;
	Jilmayganlar O = P (O [C @ H] 1O [C @@ H] ([C @@ H] (O) [C @ H] (O) [C @@ H] 1O) CO) (O) OP ( = O) (O) OC [C @ H] 4O [C @@ H] (n2c3NC (= N / C (= O) c3nc2) N) [C @ H] (O) [C @@ H] 4O;
Xususiyatlari
Kimyoviy formulalar	C16H25N5O16P2
Molyar massa	605,341 g / mol
	Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
	tasdiqlang (nima bu ?)
	Infobox ma'lumotnomalari

Guanozin difosfat mannozi yoki YaIM-mannoz a nukleotid shakar bu uchun substrat glikoziltransferaza reaktsiyalar metabolizm. Ushbu birikma fermentlar uchun substrat deb ataladi mannosiltransferazlar.

Barcha glikolitik reaktsiyalarda faollashtirilgan mannoz donori sifatida tanilgan, YaK-mannoz eukaryotlarda muhim ahamiyatga ega.^[1]

Biosintez

YaIM-mannoz ishlab chiqariladi GTP va mannoz-6-fosfat ferment tomonidan mannoz-1-fosfat guanililtransferaza.^[2]

Nukleootidil-transferaza oilasiga kiruvchi fermentlardan biri YaIM-Mannoz Pirofosforilaza (YaIM-MP) bakteriyalar, zamburug'lar, o'simliklar va hayvonlarda uchraydigan keng tarqalgan fermentdir.^[3]

Adabiyotlar

^ Styuart, Jeyms; Kertis, Joan; Spurck, Timoti P.; Ilg, Tomas; Garami, Attila; Bolduin, Treysi; Kret, Natali; McFadden, Geoffrey I.; Devis, Antoniy; Handman, Emanuela (2005 yil iyul). "Guanozin difosfat-mannozli pirofosforilaza mavjud bo'lmagan Leishmania meksikanasi nokautining xarakteristikasi". Xalqaro parazitologiya jurnali. 35 (8): 861–873. doi:10.1016 / j.ijpara.2005.03.008. PMID 15936761.
^ Samuel G, Rivz P (2003). "O-antigenlarining biosintezi: nukleotid qandli prekursor sintezi va O-antigen yig'ilishida ishtirok etgan genlar va yo'llar". Karbongidrat tadqiqotlari. 338 (23): 2503–19. doi:10.1016 / j.carres.2003.07.009. PMID 14670712.
^ Pomel, Sebastyan; Mao, Vey; Xa-Duong, Tap; Kave, xristian; Loiseau, Filipp M. (2019-05-31). "Yalpi ichki mahsulot-Mannozli pirofosforilaza: Leyshmaniozga qarshi dori vositalarining biologik jihatdan tasdiqlangan maqsadi". Uyali va infektsion mikrobiologiyaning chegaralari. 9: 186. doi:10.3389 / fcimb.2019.00186. ISSN 2235-2988. PMC 6554559. PMID 31214516.

Shuningdek qarang

Bu biokimyo maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

[1] Styuart, Jeyms; Kertis, Joan; Spurck, Timoti P.; Ilg, Tomas; Garami, Attila; Bolduin, Treysi; Kret, Natali; McFadden, Geoffrey I.; Devis, Antoniy; Handman, Emanuela (2005 yil iyul). "Guanozin difosfat-mannozli pirofosforilaza mavjud bo'lmagan Leishmania meksikanasi nokautining xarakteristikasi". Xalqaro parazitologiya jurnali. 35 (8): 861–873. doi:10.1016 / j.ijpara.2005.03.008. PMID 15936761.

[Reeves-2] Samuel G, Rivz P (2003). "O-antigenlarining biosintezi: nukleotid qandli prekursor sintezi va O-antigen yig'ilishida ishtirok etgan genlar va yo'llar". Karbongidrat tadqiqotlari. 338 (23): 2503–19. doi:10.1016 / j.carres.2003.07.009. PMID 14670712.

[3] Pomel, Sebastyan; Mao, Vey; Xa-Duong, Tap; Kave, xristian; Loiseau, Filipp M. (2019-05-31). "Yalpi ichki mahsulot-Mannozli pirofosforilaza: Leyshmaniozga qarshi dori vositalarining biologik jihatdan tasdiqlangan maqsadi". Uyali va infektsion mikrobiologiyaning chegaralari. 9: 186. doi:10.3389 / fcimb.2019.00186. ISSN 2235-2988. PMC 6554559. PMID 31214516.

[1]

[2]

[3]

Ismlar

IUPAC nomi [(2R, 3S, 4R, 5R) -5- (2-amino-6-okso-1,6-dihidro-9H-purin-9-yl) -3,4-dihidroksitetrahidrofuran-2-il] metil (2R , 3S, 4S, 5S, 6R) -3,4,5-trihidroksi-6- (gidroksimetil) tetrahidro-2H-piran-2-il dihidrogen difosfat
Identifikatorlar
CAS raqami	3123-67-9^Y
3D model (JSmol )	Interaktiv rasm
ChEBI	CHEBI: 15820^Y
ChemSpider	17372^Y
MeSH	Guanosin + Difosfat + Mannoz
PubChem CID	18396
UNII	SA0B77H8CS^Y
InChI InChI = 1S / C16H25N5O16P2 / c17-16-19-12-6 (13 (28) 20-16) 18-3-21 (12) 14-10 (26) 8 (24) 5 (34-14) 2- 33-38 (29,30) 37-39 (31,32) 36-15-11 (27) 9 (25) 7 (23) 4 (1-22) 35-15 / h3-5,7-11, 14-15,22-27H, 1-2H2, (H, 29,30) (H, 31,32) (H3,17,19,20,28) / t4-, 5-, 7-, 8-, 9 +, 10-, 11 +, 14-, 15- / m1 / s1^Y Kalit: MVMSCBBUIHUTGJ-GDJBGNAASA-N^Y InChI = 1 / C16H25N5O16P2 / c17-16-19-12-6 (13 (28) 20-16) 18-3-21 (12) 14-10 (26) 8 (24) 5 (34-14) 2- 33-38 (29,30) 37-39 (31,32) 36-15-11 (27) 9 (25) 7 (23) 4 (1-22) 35-15 / h3-5,7-11, 14-15,22-27H, 1-2H2, (H, 29,30) (H, 31,32) (H3,17,19,20,28) / t4-, 5-, 7-, 8-, 9 +, 10-, 11 +, 14-, 15- / m1 / s1 Kalit: MVMSCBBUIHUTGJ-GDJBGNAABK
Jilmayganlar O = P (O [C @ H] 1O [C @@ H] ([C @@ H] (O) [C @ H] (O) [C @@ H] 1O) CO) (O) OP ( = O) (O) OC [C @ H] 4O [C @@ H] (n2c3NC (= N / C (= O) c3nc2) N) [C @ H] (O) [C @@ H] 4O
Xususiyatlari
Kimyoviy formulalar	C₁₆H₂₅N₅O₁₆P₂
Molyar massa	605,341 g / mol
Boshqacha ko'rsatilmagan hollar bundan mustasno, ulardagi materiallar uchun ma'lumotlar keltirilgan standart holat (25 ° C [77 ° F], 100 kPa da).
Y tasdiqlang (nima bu ^YN ?)
Infobox ma'lumotnomalari